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expression analysis of candidate breast tumour suppressor genes on ...
e-cadherin at 16q22 was identified as a tsg in lobular breast cancer, but tsgs in ductal breast cancer remain elusive. several genes have been suggested as potential candidates (eg cbfa2t3, ctcf and wwox) but no inactivating mutations ...
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Pax6 Regulation in Retinal Cells by CCCTC Binding Factor -- Li et ...
A widely expressed transcription factor with multiple DNA sequence specificity, CTCF, is localized at chromosome segment 16q22.1 within one of the smallest regions of overlap for common deletions in breast and prostate cancers. ...
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Genome Biology | Full text | A sequence-based survey of the ...
Recently, a 360-kb segmental duplication containing the HYDIN locus was identified on chromosome 1q21.1 [28]. This duplication event created the HYDIN fusion gene and explains the observed apparent 1q21.1;16q22.2 translocation. ...
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World Journal of Surgical Oncology | Full text | Aberrant E ...
Alterations in the gene CDH1 on chromosome 16q22 are associated with changes in E-cadherin protein expression and function. Inactivation of E-cadherin in lobular carcinomas and certain diffuse gastric carcinomas may play a role in the ...
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Minimal 16q Genomic Loss Implicates Cadherin-11 in Retinoblastoma
We now define a 2.62 Mbp minimal region of genomic loss of chromosome 16q22, which is likely to contain tumor suppressor gene(s), in 76 retinoblastoma tumors, using loss of heterozygosity (30 of 76 tumors) and quantitative multiplex PCR ...
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Ocular Pathology: What is macular dystrophy of the cornea?
The gene involved in macular dystrophy is a carbohydrate sulfotransferase gene (CHST6) on chromosome 16q22. Two types of macular dystrophy have been described depending on the absence in the production of keratan sulfate (type I) and ...
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Breast Cancer Research | Full text | A critical evaluation of loss ...
Genetic aberrations that affect chromosome arms 7p, 16q, 17p and 17q seem to be early events [11]. LOH at region 16q22.2-q23.2 seems to be a major event in the genesis of metastases [15]. During tumorigenesis free DNA may be released ...
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Breast Cancer Research | Full text | P-cadherin expression in ...
It also maps to chromosome 16q22.1, a region that contains a cluster of several cadherin genes, just 32 kilobases upstream of the gene encoding human E-cadherin [5,6]. Mutations in the CDH3 gene have been reported to be responsible for ...
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Germline E-cadherin mutations in familial lobular breast cancer ...
The CDH1 (epithelial cadherin, OMIM 192090 [OMIM] ) gene is composed of 16 exons located on chromosome 16q22.1.2 The calcium-dependent molecule E-cadherin, a key regulator of cell adhesion, is the protein product of CDH1,3 and is ...
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Biological and functional analysis of statistically significant ...
Its chromosomal localization suggests that a variety of human cancers shows a deletion of this gene [48]. RPA1 (replication protein A1; Location: 17p13.3) and RPA2 (replication protein A2; Location: 1p35) are required for the ...
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